Signaling pathways of chronic kidney diseases, implications for therapeutics

Q Yuan, B Tang, C Zhang - Signal transduction and targeted therapy, 2022 - nature.com
Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …

Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease

A Mitrofanova, S Merscher, A Fornoni - Nature Reviews Nephrology, 2023 - nature.com
Chronic kidney disease (CKD) is a global health problem with rising incidence and
prevalence. Among several pathogenetic mechanisms responsible for disease progression …

Lipid accumulation and chronic kidney disease

Z Gai, T Wang, M Visentin, GA Kullak-Ublick, X Fu… - Nutrients, 2019 - mdpi.com
Obesity and hyperlipidemia are the most prevalent independent risk factors of chronic
kidney disease (CKD), suggesting that lipid accumulation in the renal parenchyma is …

Fatty acid-induced lipotoxicity in pancreatic beta-cells during development of type 2 diabetes

YS Oh, GD Bae, DJ Baek, EY Park… - Frontiers in …, 2018 - frontiersin.org
Type 2 diabetes is caused by chronic insulin resistance and progressive decline in beta-cell
function. Optimal beta-cell function and mass is essential for glucose homeostasis and beta …

Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages

SM Anil, N Shalev, AC Vinayaka, S Nadarajan… - Scientific reports, 2021 - nature.com
Cannabis sativa is widely used for medical purposes and has anti-inflammatory activity. This
study intended to examine the anti-inflammatory activity of cannabis on immune response …

Lipidomic approaches to dissect dysregulated lipid metabolism in kidney disease

J Baek, C He, F Afshinnia, G Michailidis… - Nature Reviews …, 2022 - nature.com
Dyslipidaemia is a hallmark of chronic kidney disease (CKD). The severity of dyslipidaemia
not only correlates with CKD stage but is also associated with CKD-associated …

Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes

LD Ly, S Xu, SK Choi, CM Ha, T Thoudam… - … & molecular medicine, 2017 - nature.com
Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and
ATP synthesis but also cause serious stress to various tissues, contributing to the …

Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells

J Gong, Y Lin, H Zhang, C Liu, Z Cheng, X Yang… - Cell death & …, 2020 - nature.com
Metabolic interaction between cancer-associated fibroblasts (CAFs) and colorectal cancer
(CRC) cells plays a major role in CRC progression. However, little is known about lipid …

CD36 in chronic kidney disease: novel insights and therapeutic opportunities

X Yang, DM Okamura, X Lu, Y Chen… - Nature Reviews …, 2017 - nature.com
CD36 (also known as scavenger receptor B2) is a multifunctional receptor that mediates the
binding and cellular uptake of long-chain fatty acids, oxidized lipids and phospholipids …

Mitochondria in diabetic kidney disease

AA Ahmad, SO Draves, M Rosca - Cells, 2021 - mdpi.com
Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD) in
the USA. The pathogenesis of DKD is multifactorial and involves activation of multiple …