The transactivation domain of the cAMP response element-binding protein (CREB) consists
of two major domains. The glutamine-rich Q2 domain, which interacts with the general …

The increase in life expectancy seen in many countries has been accompanied by an
increase in the number of people living with dementia and a growing need for health care …

The nervous and vascular systems, although functionally different, share many common
regulators of function maintenance. Long non‐coding RNA s (lnc RNA s) are important …

In multiple sclerosis (MS), long-term disability is primarily caused by axonal and neuronal
damage. We demonstrated in a previous study that neuronal apoptosis occurs early during …

Gangliosides, sialic acid-containing sphingolipids, are major constituents of neuronal
membranes. According to the number of sialic acids and the structure of the oligosaccharide …

Glycosphingolipids are ubiquitous membrane constituents that are subdivided in neutral or
acidic fractions (gangliosides and sulfatides). Their analysis requires extraction and …

Neural stem/progenitor cells (NPCs) self-renew and differentiate, generating neuronal and
non-neuronal (glial) cell lineages. Although a number of factors, including transcription …

cAMP is a key regulatory molecule that controls many important processes in the retina,
including phototransduction, cell development and death, growth of neural processes …

Background Cell-to-cell communication is vital for tissues to respond, adapt, and thrive in the
prevailing milieu. Several mechanisms mediate intercellular signaling, including tunneling …

Neurotrophins play important roles in the response of adult neurons to injury. The
intracellular signaling mechanisms used by neurotrophins to regulate survival and axon …