Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …

The pivotal role of lysosomes in cellular processes is increasingly appreciated. An
understanding of the balanced interplay between the activity of acidic hydrolases, lysosomal …

To mediate the degradation of biomacromolecules, lysosomes must traffic towards cargo-
carrying vesicles for subsequent membrane fusion or fission. Mutations of the lysosomal …

Late endosomes (LEs) have characteristic intracellular distributions determined by their
interactions with various motor proteins. Motor proteins associated to the dynactin subunit …

The endothelium, which forms the inner cellular lining of blood vessels and lymphatics, is a
highly metabolically active organ that is involved in many physiopathological processes …

Salmonella enterica serovars cause severe disease in humans, such as gastroenteritis and
typhoid fever. The bacteria are able to invade and replicate within host cells, including …

The transfer of cholesterol from the outer to the inner mitochondrial membrane is the rate-
limiting step in hormone-induced steroid formation. To ensure that this step is achieved …

Cells use secreted signals (eg chemokines and growth factors) and sophisticated vehicles
such as argosomes, cytonemes, tunneling nanotubes and exosomes to relay important …

Introduction• Cavolae on the plasma membrane• Internalization of caveolae‐Are caveolae
stable, immobile invaginations at the plasma membrane?‐Caveolar budding and pinching …

BACKGROUND & AIMS: Some studies have indicated that dietary cholesterol has a role in
the progression of liver fibrosis. We investigated the mechanisms by which dietary …