Actin dynamics, architecture, and mechanics in cell motility

L Blanchoin, R Boujemaa-Paterski… - Physiological …, 2014 - journals.physiology.org
Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch

LB Case, CM Waterman - Nature cell biology, 2015 - nature.com
During cell migration, the forces generated in the actin cytoskeleton are transmitted across
transmembrane receptors to the extracellular matrix or other cells through a series of …

Hydrodynamics of soft active matter

MC Marchetti, JF Joanny, S Ramaswamy… - Reviews of modern …, 2013 - APS
This review summarizes theoretical progress in the field of active matter, placing it in the
context of recent experiments. This approach offers a unified framework for the mechanical …

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

JT Parsons, AR Horwitz, MA Schwartz - Nature reviews Molecular cell …, 2010 - nature.com
Cell migration affects all morphogenetic processes and contributes to numerous diseases,
including cancer and cardiovascular disease. For most cells in most environments …

[HTML][HTML] Cell migration

X Trepat, Z Chen, K Jacobson - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
Cell migration is fundamental to establishing and maintaining the proper organization of
multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell …

Environmental sensing through focal adhesions

B Geiger, JP Spatz, AD Bershadsky - Nature reviews Molecular cell …, 2009 - nature.com
Recent progress in the design and application of artificial cellular microenvironments and
nanoenvironments has revealed the extraordinary ability of cells to adjust their cytoskeletal …

Mechanism of shape determination in motile cells

K Keren, Z Pincus, GM Allen, EL Barnhart, G Marriott… - Nature, 2008 - nature.com
The shape of motile cells is determined by many dynamic processes spanning several
orders of magnitude in space and time, from local polymerization of actin monomers at …

[HTML][HTML] The forces behind cell movement

R Ananthakrishnan, A Ehrlicher - International journal of biological …, 2007 - ncbi.nlm.nih.gov
Cell movement is a complex phenomenon primarily driven by the actin network beneath the
cell membrane, and can be divided into three general components: protrusion of the leading …

Active behavior of the cytoskeleton

F Juelicher, K Kruse, J Prost, JF Joanny - Physics reports, 2007 - Elsevier
This review presents some of our recent results on active polar gels. Active polar gels are
viscoelastic materials formed by polar filaments which are maintained in a non-equilibrium …

Coupling actin flow, adhesion, and morphology in a computational cell motility model

D Shao, H Levine, WJ Rappel - Proceedings of the …, 2012 - National Acad Sciences
Cell migration is a pervasive process in many biology systems and involves protrusive
forces generated by actin polymerization, myosin dependent contractile forces, and force …