Lower motor neuron (LMN) syndromes typically present with muscle wasting and weakness
and may arise from pathology affecting the distal motor nerve up to the level of the anterior …

Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy's disease, is a rare, X-
linked hereditary lower motor neuron disease, characterized by progressive muscular …

Spinobulbar muscular atrophy (SBMA) is caused by CAG expansions in the androgen
receptor gene. Androgen binding to polyQ-expanded androgen receptor triggers SBMA …

Spinal muscular atrophy (SMA) is an autosomal recessive genetic disorder leading to
paralysis, muscle atrophy, and death. Significant advances in antisense oligonucleotide …

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by the
expansion of a polyglutamine tract in the androgen receptor (AR). The mechanism by which …

Serum creatinine has been indicated as a potential marker of motor function in SBMA and
results form previous longitudinal studies pointed to its decline over time. This is a …

Kennedy's disease, or spinal and bulbar muscular atrophy (SBMA), is an X-linked
neuromuscular condition clinically characterised by weakness, atrophy and fasciculations of …

Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy's disease, is a
debilitating neuromuscular disease characterized by progressive muscular weakness and …

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disorder caused by
polyglutamine expansion in the androgen receptor (AR) and characterized by the loss of …

Prior studies showed that polyglutamine-expanded androgen receptor (AR) is aberrantly
acetylated and that deacetylation of the mutant AR by overexpression of nicotinamide …