Rethinking human cytomegalovirus latency reservoir

M Schwartz, N Stern‐Ginossar - … of the New York Academy of …, 2023 - Wiley Online Library
Human cytomegalovirus (HCMV) is a prevalent herpesvirus, infecting the majority of the
human population. Like other herpesviruses, it causes lifelong infection through the …

Where do we stand after decades of studying human cytomegalovirus?

F Gugliesi, A Coscia, G Griffante, G Galitska… - Microorganisms, 2020 - mdpi.com
Human cytomegalovirus (HCMV), a linear double-stranded DNA betaherpesvirus belonging
to the family of Herpesviridae, is characterized by widespread seroprevalence, ranging …

Cellular reservoirs of latent cytomegaloviruses

MJ Reddehase, NAW Lemmermann - Medical microbiology and …, 2019 - Springer
Cytomegaloviruses (CMVs), members of the β-subfamily of the herpesvirus family, have co-
speciated with their respective mammalian hosts resulting in a mutual virus–host adaptation …

Bright and early: Inhibiting human cytomegalovirus by targeting major immediate-early gene expression or protein function

CS Adamson, MM Nevels - Viruses, 2020 - mdpi.com
The human cytomegalovirus (HCMV), one of eight human herpesviruses, establishes
lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections …

HCMV antivirals and strategies to target the latent reservoir

MR Perera, MR Wills, JH Sinclair - Viruses, 2021 - mdpi.com
Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. In healthy people,
primary infection is generally asymptomatic, and the virus can go on to establish lifelong …

A cytomegalovirus inflammasome inhibitor reduces proinflammatory cytokine release and pyroptosis

Y Deng, E Ostermann, W Brune - Nature communications, 2024 - nature.com
In response to viral infection, cells can initiate programmed cell death (PCD), leading to a
reduction in the release of viral progeny. Viruses have therefore evolved specific …

A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis

ND Bergkamp, JR van Senten, HJ Brink… - Science …, 2023 - science.org
The G protein–coupled receptor (GPCR) US28 encoded by the human cytomegalovirus
(HCMV) is associated with accelerated progression of glioblastomas, aggressive brain …

Alternative promoters drive human cytomegalovirus reactivation from latency

D Collins-McMillen, M Rak… - Proceedings of the …, 2019 - National Acad Sciences
Reactivation from latency requires reinitiation of viral gene expression and culminates in the
production of infectious progeny. The major immediate early promoter (MIEP) of human …

The differentiation of human cytomegalovirus infected-monocytes is required for viral replication

CK Min, AK Shakya, BJ Lee, DN Streblow… - Frontiers in Cellular …, 2020 - frontiersin.org
Viral dissemination is a key mechanism responsible for persistence and disease following
human cytomegalovirus (HCMV) infection. Monocytes play a pivotal role in viral …

Stochastic episodes of latent cytomegalovirus transcription drive CD8 T-cell “memory inflation” and avoid immune evasion

M Griessl, A Renzaho, K Freitag, CK Seckert… - Frontiers in …, 2021 - frontiersin.org
Acute infection with murine cytomegalovirus (mCMV) is controlled by CD8+ T cells and
develops into a state of latent infection, referred to as latency, which is defined by lifelong …