Molecular mechanism of HIV-1 entry
B Chen - Trends in microbiology, 2019 - cell.com
HIV-1 envelope glycoprotein [Env; trimeric (gp160) 3 cleaved to (gp120/gp41) 3] attaches
the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate …
the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate …
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease
EA Berger, PM Murphy, JM Farber - Annual review of …, 1999 - annualreviews.org
▪ Abstract In addition to CD4, the human immunodeficiency virus (HIV) requires a coreceptor
for entry into target cells. The chemokine receptors CXCR4 and CCR5, members of the G …
for entry into target cells. The chemokine receptors CXCR4 and CCR5, members of the G …
Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1
EJ Platt, K Wehrly, SE Kuhmann, B Chesebro… - Journal of …, 1998 - Am Soc Microbiol
It has been proposed that changes in cell surface concentrations of coreceptors may control
infections by human immunodeficiency virus type 1 (HIV-1), but the mechanisms of …
infections by human immunodeficiency virus type 1 (HIV-1), but the mechanisms of …
Structural basis of coreceptor recognition by HIV-1 envelope spike
MM Shaik, H Peng, J Lu, S Rits-Volloch, C Xu, M Liao… - Nature, 2019 - nature.com
Abstract HIV-1 envelope glycoprotein (Env), which consists of trimeric (gp160) 3 cleaved to
(gp120 and gp41) 3, interacts with the primary receptor CD4 and a coreceptor (such as …
(gp120 and gp41) 3, interacts with the primary receptor CD4 and a coreceptor (such as …
[HTML][HTML] Structure of CC chemokine receptor 5 with a potent chemokine antagonist reveals mechanisms of chemokine recognition and molecular mimicry by HIV
CCR5 is the primary chemokine receptor utilized by HIV to infect leukocytes, whereas CCR5
ligands inhibit infection by blocking CCR5 engagement with HIV gp120. To guide the design …
ligands inhibit infection by blocking CCR5 engagement with HIV gp120. To guide the design …
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4
The CCR5 co-receptor binds to the HIV-1 gp120 envelope glycoprotein and facilitates HIV-1
entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the …
entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the …
Molecular mechanisms of HIV entry
Human immunodeficiency virus (HIV) entry is a complex and intricate process that facilitates
delivery of the viral genome to the host cell. The only viral surface protein, Envelope (Env), is …
delivery of the viral genome to the host cell. The only viral surface protein, Envelope (Env), is …
A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5
T Dragic, A Trkola, DAD Thompson… - Proceedings of the …, 2000 - National Acad Sciences
HIV-1 entry into CD4+ cells requires the sequential interactions of the viral envelope
glycoproteins with CD4 and a coreceptor such as the chemokine receptors CCR5 and …
glycoproteins with CD4 and a coreceptor such as the chemokine receptors CCR5 and …
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
C Huang, M Venturi, S Majeed… - Proceedings of the …, 2004 - National Acad Sciences
The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1
coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we …
coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we …
New developments in anti-HIV chemotherapy
E Clercq - Current medicinal chemistry, 2001 - ingentaconnect.com
Virtually all the compounds that are currently used, or under advanced clinical trial, for the
treatment of HIV infections, belong to one of the following classes:(i) nucleoside/nucleotide …
treatment of HIV infections, belong to one of the following classes:(i) nucleoside/nucleotide …