Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

Protein palmitoylation is an increasingly investigated form of post-translational lipid
modification that affects protein localization, accumulation, secretion and function. Recently …

Motivation The theoretical possibility of determining the state and parameters of a dynamic
model by measuring its outputs is given by its structural identifiability and its observability …

Biological processes are often modeled by ordinary differential equations with unknown
parameters. The unknown parameters are usually estimated from experimental data. In …

Many real‐world processes and phenomena are modeled using systems of ordinary
differential equations with parameters. Given such a system, we say that a parameter is …

Clinical studies have revealed that the ABCB4 gene encodes the phospholipid transporter
on the canalicular membrane of hepatocytes, and its mutations and variants are the genetic …

Many dynamical systems arising in biology and other areas exhibit multistationarity (two or
more positive steady states with the same conserved quantities). Although deciding …

We address the question of which small, bimolecular, mass action chemical reaction
networks (CRNs) are capable of Andronov–Hopf bifurcation (from here on abbreviated …

Accurate prediction of post-translational modifications (PTMs) is of great significance in
understanding cellular processes, by modulating protein structure and dynamics …

This work concerns the question of how two important dynamical properties, oscillations and
bistability, emerge in an important biological signaling network. Specifically, we consider a …