Aldehyde dehydrogenase (ALDH) is a superfamily of enzymes that detoxify a variety of
endogenous and exogenous aldehydes and are required for the biosynthesis of retinoic …

The human genome contains 19 putatively functional aldehyde dehydrogenase (ALDH)
genes, which encode enzymes critical for detoxification of endogenous and exogenous …

One of the current stumbling blocks in our fight against cancer is the development of
acquired resistance to therapy, which is attributable to approximately 90% of cancer-related …

Recent evidence suggests that enhanced aldehyde dehydrogenase (ALDH) activity is a
hallmark of cancer stem cells (CSC) measurable by the aldefluor assay. ALDH1A1, one of …

Normal stem cells and cancer stem cells (CSCs) share similar properties, in that both have
the capacity to self-renew and differentiate into multiple cell types. In both the normal stem …

Background and Aim The study of CD44/CD24 and ALDH1 expression is the most accurate
method to identify cancer stem cells (CSC) from breast cancer populations. However, the …

Cancer stem cells (CSCs) are proposed to initiate cancer and propagate metastasis. Breast
CSCs identified by aldehyde dehydrogenase (ALDH) activity are highly tumorigenic in …

Resistance to current chemotherapeutic or radiation-based cancer treatment strategies is a
serious concern. Cancer stem cells (CSCs) are typically able to evade treatment and …

Aldehyde dehydrogenase isoform 1 (ALDH1) has been proved useful for the identification of
cancer stem cells. However, our knowledge of the expression and activity of ALDH1 in …

Many, if not all, tumours contain a sub‐population of self‐renewing and expanding stem
cells known as cancer stem cells (CSCs). The symmetric division of CSCs is one mechanism …