MicrobiomeAnalyst 2.0: comprehensive statistical, functional and integrative analysis of microbiome data

Y Lu, G Zhou, J Ewald, Z Pang, T Shiri… - Nucleic Acids …, 2023 - academic.oup.com
Microbiome studies have become routine in biomedical, agricultural and environmental
sciences with diverse aims, including diversity profiling, functional characterization, and …

Statistical normalization methods in microbiome data with application to microbiome cancer research

Y Xia - Gut Microbes, 2023 - Taylor & Francis
Mounting evidence has shown that gut microbiome is associated with various cancers,
including gastrointestinal (GI) tract and non-GI tract cancers. But microbiome data have …

Multivariable association discovery in population-scale meta-omics studies

H Mallick, A Rahnavard, LJ McIver, S Ma… - PLoS computational …, 2021 - journals.plos.org
It is challenging to associate features such as human health outcomes, diet, environmental
conditions, or other metadata to microbial community measurements, due in part to their …

Multi-kingdom microbiota analyses identify bacterial–fungal interactions and biomarkers of colorectal cancer across cohorts

NN Liu, N Jiao, JC Tan, Z Wang, D Wu, AJ Wang… - Nature …, 2022 - nature.com
Despite recent progress in our understanding of the association between the gut
microbiome and colorectal cancer (CRC), multi-kingdom gut microbiome dysbiosis in CRC …

Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes

Z Mei, F Wang, A Bhosle, D Dong, R Mehta, A Ghazi… - Nature medicine, 2024 - nature.com
The association of gut microbial features with type 2 diabetes (T2D) has been inconsistent
due in part to the complexity of this disease and variation in study design. Even in cases in …

Critical review of 16S rRNA gene sequencing workflow in microbiome studies: From primer selection to advanced data analysis

A Regueira‐Iglesias, C Balsa‐Castro… - Molecular Oral …, 2023 - Wiley Online Library
The multi‐batch reanalysis approach of jointly reevaluating gene/genome sequences from
different works has gained particular relevance in the literature in recent years. The large …

Multikingdom and functional gut microbiota markers for autism spectrum disorder

Q Su, OWH Wong, W Lu, Y Wan, L Zhang, W Xu… - Nature …, 2024 - nature.com
Associations between the gut microbiome and autism spectrum disorder (ASD) have been
investigated although most studies have focused on the bacterial component of the …

Population structure discovery in meta-analyzed microbial communities and inflammatory bowel disease using MMUPHin

S Ma, D Shungin, H Mallick, M Schirmer, LH Nguyen… - Genome Biology, 2022 - Springer
Microbiome studies of inflammatory bowel diseases (IBD) have achieved a scale for meta-
analysis of dysbioses among populations. To enable microbial community meta-analyses …

Multi-kingdom gut microbiota analyses define bacterial-fungal interplay and microbial markers of pan-cancer immunotherapy across cohorts

X Huang, M Hu, T Sun, J Li, Y Zhou, Y Yan, B Xuan… - Cell Host & Microbe, 2023 - cell.com
The effect of gut bacteria on the response to immune checkpoint inhibitors (ICIs) has been
studied, but the relationship between fungi and ICI responses is not fully understood. Herein …

Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes

KN Thompson, KS Bonham, NE Ilott… - Science translational …, 2023 - science.org
Musculoskeletal diseases affect up to 20% of adults worldwide. The gut microbiome has
been implicated in inflammatory conditions, but large-scale metagenomic evaluations have …