Abstract DNA methylation (5-methylcytosine (5mC)) is critical for genome stability and
transcriptional regulation in mammals. The discovery that ten-eleven translocation (TET) …

The intracellular ATP-ribosyltransferases PARP1 and PARP2, contribute to DNA base
excision repair (BER) and DNA demethylation and have been implicated in epigenetic …

Mammalian development begins in transcriptional silence followed by a period of
widespread activation of thousands of genes. DNA methylation reprogramming is integral to …

Ten-eleven translocation-2 (TET2) is a crucial driver of cell fate outcomes in a myriad of
biological processes, including embryonic development and tissue homeostasis. TET2 …

Genome-wide DNA demethylation is a unique feature of mammalian development and
naïve pluripotent stem cells. Here, we describe a recently evolved pathway in which global …

The establishment of cellular identity is driven by transcriptional and epigenetic regulators of
the chromatin proteome-the chromatome. Comprehensive analyses of the chromatome …

The activation of molecular oxygen for the highly selective functionalization and repair of
DNA and RNA nucleobases is achieved by α‐ketoglutarate (α‐KG)/iron‐dependent …

Ten eleven translocation (TET) dioxygenases 1–3 are non-heme Fe (II) and α-ketoglutarate
dependent enzymes that catalyze oxidation of 5-methylcytosine (5mC) in DNA to …

Epigenetic alterations are increasingly recognized as important contributors to the
development and progression of pancreatic ductal adenocarcinoma. 5 …

Epigenetic programming of cells requires methylation of deoxycytidines (dC) to 5‐methyl‐dC
(mdC) followed by oxidation to 5‐hydroxymethyl‐dC (hmdC), 5‐formyl‐dC (fdC), and 5 …