Computational pharmaceutics-A new paradigm of drug delivery
In recent decades pharmaceutics and drug delivery have become increasingly critical in the
pharmaceutical industry due to longer time, higher cost, and less productivity of new …
pharmaceutical industry due to longer time, higher cost, and less productivity of new …
A review of respiratory anatomical development, air flow characterization and particle deposition
The understanding of complex inhalation and transport processes of pollutant particles
through the human respiratory system is important for investigations into dosimetry and …
through the human respiratory system is important for investigations into dosimetry and …
Computational analysis of aerosol-dynamics in a human whole-lung airway model
AV Kolanjiyil, C Kleinstreuer - Journal of Aerosol Science, 2017 - Elsevier
Prediction of the air-particle dynamics in human lungs can reveal critical deposition sites of
toxins or can determine best physical parameters for direct drug delivery and associated …
toxins or can determine best physical parameters for direct drug delivery and associated …
Role of CFD based in silico modelling in establishing an in vitro-in vivo correlation of aerosol deposition in the respiratory tract
Effective evaluation and prediction of aerosol transport deposition in the human respiratory
tracts are critical to aerosol drug delivery and evaluation of inhalation products …
tracts are critical to aerosol drug delivery and evaluation of inhalation products …
Scientific and regulatory activities initiated by the US food and drug administration to foster approvals of generic dry powder inhalers: bioequivalence perspective
Regulatory science for generic dry powder inhalers (DPIs) in the United States (US) has
evolved over the last decade. In 2013, the US Food and Drug Administration (FDA) …
evolved over the last decade. In 2013, the US Food and Drug Administration (FDA) …
Dry powder inhaler aerosol deposition in a model of tracheobronchial airways: Validating CFD predictions with in vitro data
Effective drug delivery into the lungs plays an important role in management of pulmonary
diseases that affect millions all around the world. The main objective of this investigation is …
diseases that affect millions all around the world. The main objective of this investigation is …
[HTML][HTML] A critical analysis of the CFD-DEM simulation of pharmaceutical aerosols deposition in extra-thoracic airways
Recent advances in the characterization of the human respiratory system and in multi-phase
flow dynamics in complex geometries have led numerical simulations to play an expanding …
flow dynamics in complex geometries have led numerical simulations to play an expanding …
Effect of swirling flow and particle-release pattern on drug delivery to human tracheobronchial airways
MH Taheri, O Pourmehran, MM Sarafraz… - … and Modeling in …, 2021 - Springer
The present study aims to investigate the effect of swirling flow on particle deposition in a
realistic human airway. A computational fluid dynamic (CFD) model was utilized for the …
realistic human airway. A computational fluid dynamic (CFD) model was utilized for the …
Validating CFD predictions of nasal spray deposition: Inclusion of cloud motion effects for two spray pump designs
Momentum transfer from nasal spray droplets to the surrounding gas may create droplet
cloud motion and influence nasal deposition patterns. The objective of this study was to …
cloud motion and influence nasal deposition patterns. The objective of this study was to …
Euler-Lagrange prediction of diesel-exhaust polydisperse particle transport and deposition in lung: Anatomy and turbulence effects
In clinical assessments, the correlation between atmospheric air pollution and respiratory
damage is highly complicated. Epidemiological studies show that atmospheric air pollution …
damage is highly complicated. Epidemiological studies show that atmospheric air pollution …