Calcineurin-NFAT signaling is critical for numerous aspects of vertebrate function during and
after embryonic development. Initially discovered in T cells, the NFAT gene family, consisting …

In Alzheimer's disease, amyloid deposits along the brain vasculature lead to a condition
known as cerebral amyloid angiopathy (CAA), which impairs blood–brain barrier (BBB) …

Accumulation of misfolded/unfolded aggregated proteins in the brain is a hallmark of many
neurodegenerative diseases affecting humans and animals. Dysregulation of calcium (Ca …

* Ethel Percy Andrus Gerontology Center, and Division of Molecular & Computational
Biology, The University of Southern California, Los Angeles, California, USA;† Department …

Chronic autoimmune inflammation, which is commonly observed in rheumatoid arthritis
(RA), disrupts the delicate balance between bone resorption and formation causing …

P-Rex1 (PIP3-dependent Rac exchanger 1, PREX1) is a Dbl-type guanine-nucleotide
exchange factor (GEF) that activates Rac-like small G proteins (small GTPases). P-Rex1 was …

The regulator of calcineurin (RCAN) was first reported as a novel gene called DSCR1,
encoded in a region termed the Down syndrome critical region (DSCR) of human …

Calcineurin phosphatase plays a crucial role in T cell activation. Dephosphorylation of the
nuclear factors of activated T cells (NFATs) by calcineurin is essential for activating cytokine …

Malignant hyperthermia (MH) and central core disease in humans have been associated
with mutations in the skeletal ryanodine receptor (RyR1). Heterozygous mice expressing the …

CD28 provides the prototypical costimulatory signal required for productive T-cell activation.
Known molecular consequences of CD28 costimulation are mostly based on studies of …