How Caenorhabditis elegans Senses Mechanical Stress, Temperature, and Other Physical Stimuli

MB Goodman, P Sengupta - Genetics, 2019 - academic.oup.com
Caenorhabditis elegans lives in a complex habitat in which they routinely experience large
fluctuations in temperature, and encounter physical obstacles that vary in size and …

Reafference and the origin of the self in early nervous system evolution

G Jékely, P Godfrey-Smith… - … Transactions of the …, 2021 - royalsocietypublishing.org
Discussions of the function of early nervous systems usually focus on a causal flow from
sensors to effectors, by which an animal coordinates its actions with exogenous changes in …

Nested neuronal dynamics orchestrate a behavioral hierarchy across timescales

HS Kaplan, OS Thula, N Khoss, M Zimmer - Neuron, 2020 - cell.com
Classical and modern ethological studies suggest that animal behavior is organized
hierarchically across timescales, such that longer-timescale behaviors are composed of …

Brain-wide representations of behavior spanning multiple timescales and states in C. elegans

AA Atanas, J Kim, Z Wang, E Bueno, MC Becker… - Cell, 2023 - cell.com
Changes in an animal's behavior and internal state are accompanied by widespread
changes in activity across its brain. However, how neurons across the brain encode …

PIEZO acts in an intestinal valve to regulate swallowing in C. elegans

YJ Park, J Yeon, J Cho, DY Kim, X Bai, Y Oh… - Nature …, 2024 - nature.com
Sensations of the internal state of the body play crucial roles in regulating the physiological
processes and maintaining homeostasis of an organism. However, our understanding of …

Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans

N Cermak, SK Yu, R Clark, YC Huang, SN Baskoylu… - Elife, 2020 - elifesciences.org
Animal behaviors are commonly organized into long-lasting states that coordinately impact
the generation of diverse motor outputs such as feeding, locomotion, and grooming …

An asymmetric mechanical code ciphers curvature-dependent proprioceptor activity

R Das, LC Lin, F Català-Castro, N Malaiwong… - Science …, 2021 - science.org
A repetitive gait cycle is an archetypical component within the behavioral repertoire of many
animals including humans. It originates from mechanical feedback within proprioceptors to …

Brain-wide representations of ongoing behavior: a universal principle?

HS Kaplan, M Zimmer - Current opinion in neurobiology, 2020 - Elsevier
Highlights•A large fraction of the brain's instantaneous activity in worms, flies, and mice
represents the animal's ongoing behavior.•Brain-wide behavioral representations are multi …

The Prop1-like homeobox gene unc-42 specifies the identity of synaptically connected neurons

EG Berghoff, L Glenwinkel, A Bhattacharya, HS Sun… - Elife, 2021 - elifesciences.org
Many neuronal identity regulators are expressed in distinct populations of cells in the
nervous system, but their function is often analyzed only in specific isolated cellular contexts …

[HTML][HTML] Proprioception, the regulator of motor function

KM Moon, J Kim, Y Seong, BC Suh, KJ Kang… - BMB …, 2021 - ncbi.nlm.nih.gov
In animals, proper locomotion is crucial to find mates and foods and avoid predators or
dangers. Multiple sensory systems detect external and internal cues and integrate them to …