A wide range of neurodegenerative diseases (NDs), including Alzheimer's disease,
Parkinson's disease, Huntington's disease, and prion diseases, share common mechanisms …

Fueled by aging populations and continued environmental contamination, the global burden
of Parkinson's disease (PD) is increasing. The disease, or more appropriately diseases …

Neurodegenerative diseases including Alzheimer (AD) and Parkinson (PD) have attracted
attention in last decades due to their high incidence worldwide. The etiology of these …

Mitochondria fuse and divide in response to cell demands and environment. Alterations in
mitochondrial dynamics underlie various human diseases, including cancer and neurologic …

Parkinson's disease (PD) is a neurodegenerative disorder that affects about 1.5% of the
global population over 65 years of age. A hallmark feature of PD is the degeneration of the …

Parkinson's disease (PD) is a movement disorder that is characterized by the progressive
degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in …

Abstract Significance: The thioredoxin (Trx) and glutathione (GSH) systems play important
roles in maintaining the redox balance in the brain, a tissue that is prone to oxidative stress …

Damage to mitochondria can lead to the depolarization of the inner mitochondrial
membrane, thereby sensitizing impaired mitochondria for selective elimination by …

Oxidative stress (OS), caused by the imbalance between the generation and detoxification of
reactive oxygen and nitrogen species (ROS/RNS), plays an important role in brain aging …

The past 25 years have seen a major expansion of knowledge concerning the cause of
Parkinson's disease provided by an understanding of environmental and genetic factors that …