[HTML][HTML] Emerging concepts in PD-1 checkpoint biology
KE Pauken, JA Torchia, A Chaudhri, AH Sharpe… - Seminars in …, 2021 - Elsevier
The PD-1 pathway is a cornerstone in immune regulation. While the PD-1 pathway has
received considerable attention for its role in contributing to the maintenance of T cell …
received considerable attention for its role in contributing to the maintenance of T cell …
TCR signaling in T cell memory
MA Daniels, E Teixeiro - Frontiers in immunology, 2015 - frontiersin.org
T cell memory plays a critical role in our protection against pathogens and tumors. The
antigen and its interaction with the T cell receptor (TCR) is one of the initiating elements that …
antigen and its interaction with the T cell receptor (TCR) is one of the initiating elements that …
[HTML][HTML] The PD-1 pathway regulates development and function of memory CD8+ T cells following respiratory viral infection
The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the
role of this pathway during acute infection remains less clear. Here, we demonstrate that PD …
role of this pathway during acute infection remains less clear. Here, we demonstrate that PD …
Optimal generation of tissue-resident but not circulating memory T cells during viral infection requires crosspriming by DNGR-1+ dendritic cells
Despite the crucial role of tissue-resident memory T (Trm) cells in protective immunity, their
priming remains poorly understood. Here, we have shown differential priming requirements …
priming remains poorly understood. Here, we have shown differential priming requirements …
Selective inhibition of low-affinity memory CD8+ T cells by corticosteroids
A Tokunaga, D Sugiyama, Y Maeda… - Journal of Experimental …, 2019 - rupress.org
Patients treated with immune checkpoint blockade (ICB) sometimes experience immune-
related adverse events (irAEs), requiring immuno-suppressive drugs such as corticosteroids …
related adverse events (irAEs), requiring immuno-suppressive drugs such as corticosteroids …
Strong homeostatic TCR signals induce formation of self‐tolerant virtual memory CD8 T cells
Virtual memory T cells are foreign antigen‐inexperienced T cells that have acquired memory‐
like phenotype and constitute 10–20% of all peripheral CD8+ T cells in mice. Their origin …
like phenotype and constitute 10–20% of all peripheral CD8+ T cells in mice. Their origin …
The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets
T Koike, K Harada, S Horiuchi, D Kitamura - Elife, 2019 - elifesciences.org
In mice, memory B (Bmem) cells can be divided into two subpopulations: CD80hi Bmem
cells, which preferentially differentiate into plasma cells; and CD80lo Bmem cells, which …
cells, which preferentially differentiate into plasma cells; and CD80lo Bmem cells, which …
T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling
Cognate antigen signal controls CD8+ T cell priming, expansion size and effector versus
memory cell fates, but it is not known if and how it modulates the functional features of …
memory cell fates, but it is not known if and how it modulates the functional features of …
Interferon-γ couples CD8+ T cell avidity and differentiation during infection
LFK Uhl, H Cai, SL Oram, JN Mahale… - Nature …, 2023 - nature.com
Effective responses to intracellular pathogens are characterized by T cell clones with a
broad affinity range for their cognate peptide and diverse functional phenotypes. How T cell …
broad affinity range for their cognate peptide and diverse functional phenotypes. How T cell …
Asymmetric cell division safeguards memory CD8 T cell development
F Gräbnitz, D Stark, D Shlesinger, A Petkidis, M Borsa… - Cell Reports, 2023 - cell.com
The strength of T cell receptor (TCR) stimulation and asymmetric distribution of fate
determinants are both implied to affect T cell differentiation. Here, we uncover asymmetric …
determinants are both implied to affect T cell differentiation. Here, we uncover asymmetric …