Membrane potential and cancer progression

M Yang, WJ Brackenbury - Frontiers in physiology, 2013 - frontiersin.org
Membrane potential (Vm), the voltage across the plasma membrane, arises because of the
presence of different ion channels/transporters with specific ion selectivity and permeability …

The roles of K+ channels in cancer

LA Pardo, W Stühmer - Nature Reviews Cancer, 2014 - nature.com
Potassium channels are transmembrane proteins that selectively facilitate the flow of
potassium ions down an electrochemical gradient. These molecules have been studied in …

Potassium channels in cell cycle and cell proliferation

D Urrego, AP Tomczak, F Zahed… - … of the Royal …, 2014 - royalsocietypublishing.org
Normal cell-cycle progression is a crucial task for every multicellular organism, as it
determines body size and shape, tissue renewal and senescence, and is also crucial for …

Voltage-gated potassium channels as therapeutic targets

H Wulff, NA Castle, LA Pardo - Nature reviews Drug discovery, 2009 - nature.com
The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …

Role of membrane potential in the regulation of cell proliferation and differentiation

S Sundelacruz, M Levin, DL Kaplan - Stem cell reviews and reports, 2009 - Springer
Biophysical signaling, an integral regulator of long-term cell behavior in both excitable and
non-excitable cell types, offers enormous potential for modulation of important cell functions …

Bioelectric controls of cell proliferation: ion channels, membrane voltage and the cell cycle

DJ Blackiston, KA McLaughlin, M Levin - Cell cycle, 2009 - Taylor & Francis
All cells possess long-term, steady-state voltage gradients across the plasma membrane.
These transmembrane potentials arise from the combined activity of numerous ion channels …

Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis

SP Fraser, JKJ Diss, AM Chioni, ME Mycielska… - Clinical cancer …, 2005 - AACR
Purpose: Ion channel activity is involved in several basic cellular behaviors that are integral
to metastasis (eg, proliferation, motility, secretion, and invasion), although their contribution …

Voltage-gated ion channels in cancer cell proliferation

VR Rao, M Perez-Neut, S Kaja, S Gentile - Cancers, 2015 - mdpi.com
Changes of the electrical charges across the surface cell membrane are absolutely
necessary to maintain cellular homeostasis in physiological as well as in pathological …

Voltage-gated potassium channels in cell proliferation

LA Pardo - Physiology, 2004 - journals.physiology.org
It is commonly accepted that cells require K+ channels to proliferate. The role (s) of K+
channels in the process is, however, poorly understood. Cloning of K+ channel genes …

Overexpression of Eag1 potassium channels in clinical tumours

B Hemmerlein, RM Weseloh, F Mello de Queiroz… - Molecular cancer, 2006 - Springer
Background Certain types of potassium channels (known as Eag1, KCNH1, Kv10. 1) are
associated with the production of tumours in patients and in animals. We have now studied …