Investigations in the last 10 years have revealed a new category of neurological diseases
mediated by antibodies against cell surface and synaptic proteins. There are currently 16 …

Neurons can sustain high rates of synaptic transmission without exhausting their supply of
synaptic vesicles. This property relies on a highly efficient local endocytic recycling of …

Neuroinflammation with excess microglial activation and synaptic dysfunction are early
symptoms of most neurological diseases. However, how microglia-associated …

Aged proteins can become hazardous to cellular function, by accumulating molecular
damage. This implies that cells should preferentially rely on newly produced ones. We …

The gonadotropin-releasing hormone (GnRH) neurons exhibit pulse and surge modes of
activity to control fertility. They also exhibit an unusual bipolar morphology comprised of a …

Although clathrin-mediated endocytosis is thought to be the predominant mechanism of
synaptic vesicle recycling, it seems to be too slow for fast recycling. Therefore, it was …

The segregation between vesicular glutamate and GABA storage and release forms the
molecular foundation between excitatory and inhibitory neurons and guarantees the precise …

Astrocytes modulate the formation and function of glutamatergic synapses in the CNS, but
whether astrocytes modulate GABAergic synaptogenesis is unknown. We demonstrate that …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

A large body of evidence has implicated amyloid precursor protein (APP) and its proteolytic
derivatives as key players in the physiological context of neuronal synaptogenesis and …