Despite decades of research on cerebral malaria (CM) there is still a paucity of knowledge
about what actual causes CM and why certain people develop it. Although sequestration of …

Invasion by the malaria parasite, Plasmodium falciparum, brings about extensive changes in
the host red cells. These include loss of the normal discoid shape, increased rigidity of the …

Red blood cells (RBCs) contain large amounts of iron and operate in highly oxygenated
tissues. As a result, these cells encounter a continuous oxidative stress. Protective …

Plasmodium falciparum malaria kills over 500,000 children every year and has been a
scourge of humans for millennia. Owing to the co-evolution of humans and P. falciparum …

Most patients with cerebral malaria (CM) sustain cerebral microvascular sequestration of
Plasmodium falciparum-infected red blood cells (iRBCs). Although many young children are …

The human malaria parasite, P lasmodium falciparum, modifies the red blood cells (RBCs)
that it infects by exporting proteins to the host cell. One key virulence protein, P. falciparum E …

Malaria continues to cause untold hardship to inhabitants of malaria-endemic regions,
causing significant morbidity and mortality that severely impact global health and the …

The mechanisms underlying Plasmodium falciparum resistance in persons with sickle trait
have been under active investigation for more than a half century. This Perspective reviews …

Abstract PfEMP1 (erythrocyte membrane protein 1) adhesins play a pivotal role in the
pathophysiology of falciparum malaria, by mediating sequestration of Plasmodium …

Plasmodium falciparum malaria causes morbidity and mortality in African children with sickle
cell anemia (SCA), but comparisons of host responses to P falciparum between children with …