Trauma can affect any individual at any location and at any time over a lifespan. The
disruption of macrobarriers and microbarriers induces instant activation of innate immunity …

Stroke produces a powerful inflammatory cascade in the brain, but also a suppression of the
peripheral immune system, which is also called stroke-induced immunosuppression (SIIS) …

Ex vivo-loaded white blood cells (WBC) can transfer cargo to pathological foci in the central
nervous system (CNS). Here we tested affinity ligand driven in vivo loading of WBC in order …

Drug targeting to inflammatory brain pathologies such as stroke and traumatic brain injury
remains an elusive goal. Using a mouse model of acute brain inflammation induced by local …

Background Traumatic brain injury (TBI) remains one of the main causes for disability and
death worldwide. While the primary mechanical injury cannot be avoided, the prevention of …

Patients hospitalized after a moderate or severe traumatic brain injury (TBI) are at increased
risk of nosocomial infections, including bacterial pneumonia and other upper respiratory …

Abstract Approximately 20–25% of traumatic brain injury (TBI) subjects develop acute lung
injury (ALI), but the pathomechanisms of TBI-induced ALI remain poorly defined. Our …

Inflammation is the mechanism of diseases caused by microbial, autoimmune, allergic,
metabolic and physical insults that produce distinct types of inflammatory responses. This …

Acute brain injury (ABI) covers various clinical entities that may require invasive mechanical
ventilation (MV) in the intensive care unit (ICU). The goal of MV, which is to protect the lung …

Background Ischemic stroke causes brain inflammation, which we postulate may result in
lung damage. Several studies have focused on stroke-induced immunosuppression and …