Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

A great need exists for the development of new medications to treat pain resulting from
various disease states and types of injury. Given that the endogenous cannabinoid (that is …

Neurons in the spinal dorsal horn process sensory information, which is then transmitted to
several brain regions, including those responsible for pain perception. The dorsal horn …

A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive
ligatures around the common sciatic nerve. The postoperative behavior of these rats …

Inflammatory responses in the peripheral (PNS) and central nervous systems (CNS) play
key roles in the development and persistence of many pathologic pain states. 1 Certain …

The prevalence and cost of chronic pain is a major physical and mental health care problem
in the United States today. As a result, there has been a recent explosion of research on …

Neuropathic pain is triggered by lesions to the somatosensory nervous system that alter its
structure and function so that pain occurs spontaneously and responses to noxious and …

Peripheral neuropathic pain is produced by multiple etiological factors that initiate a number
of diverse mechanisms operating at different sites and at different times and expressed both …

Partial nerve injury is the main cause of causalgiform pain disorders in humans. We present
here a novel animal model of this condition. In rats we unilaterally ligated about half of the …

Many are frustrated with the lack of translational progress in the pain field, in which huge
gains in basic science knowledge obtained using animal models have not led to the …