Elevated circulating insulin levels are frequently observed in the setting of obesity and early
type 2 diabetes, as a result of insensitivity of metabolic tissues to the effects of insulin. Higher …

The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

The muscleblind-like (Mbnl) family of RNA-binding proteins plays important roles in muscle
and eye development and in myotonic dystrophy (DM), in which expanded CUG or CCUG …

Muscleblind-like (MBNL) proteins are key regulators of precursor and mature mRNA
metabolism in mammals. Based on published and novel data, we explore models of tissue …

RNA-binding protein activities are highly regulated through protein levels, intracellular
localization, and post-translation modifications. During development, mRNA processing of …

The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when
overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the …

Serine-rich splicing factor 3 (SRSF3) plays a critical role in liver function and its loss
promotes chronic liver damage and regeneration. As a consequence, genetic deletion of …

CUGBP1 and MBNL1 are developmentally regulated RNA-binding proteins that are causally
associated with myotonic dystrophy type 1. We globally determined the in vivo RNA-binding …

An increasing body of evidence connects alterations in the process of alternative splicing
with cancer development and progression. However, a direct role of splicing factors as …

This comprehensive review thoroughly explores the intricate involvement of insulin receptor
(IR) isoforms and insulin-like growth factor receptors (IGFRs) in the context of the insulin and …