Mechanosensor YAP cooperates with TGF-β1 signaling to promote myofibroblast activation and matrix stiffening in a 3D model of human cardiac fibrosis
S Ragazzini, F Scocozza, G Bernava, F Auricchio… - Acta Biomaterialia, 2022 - Elsevier
Cardiac fibrosis is characterized by a maladaptive remodeling of the myocardium, which is
controlled by various inflammatory pathways and cytokines. This remodeling is …
controlled by various inflammatory pathways and cytokines. This remodeling is …
Nonlinear Elastic Bottlebrush Polymer Hydrogels Modulate Actomyosin Mediated Protrusion Formation in Mesenchymal Stromal Cells
The nonlinear elasticity of many tissue‐specific extracellular matrices is difficult to
recapitulate without the use of fibrous architectures, which couple strain‐stiffening with …
recapitulate without the use of fibrous architectures, which couple strain‐stiffening with …
A strategy to quantify myofibroblast activation on a continuous spectrum
Myofibroblasts are a highly secretory and contractile cell phenotype that are predominant in
wound healing and fibrotic disease. Traditionally, myofibroblasts are identified by the de …
wound healing and fibrotic disease. Traditionally, myofibroblasts are identified by the de …
[HTML][HTML] Functional differences in human aortic valve interstitial cells from patients with varying calcific aortic valve disease
Calcific aortic valve disease (CAVD) is characterized by progressive stiffening of aortic valve
(AV) tissues, inducing stenosis and insufficiency. Bicuspid aortic valve (BAV) is a common …
(AV) tissues, inducing stenosis and insufficiency. Bicuspid aortic valve (BAV) is a common …
Matrix Metalloproteinase‐Responsive Controlled Release of Self‐Assembly Nanoparticles Accelerates Heart Valve Regeneration In Situ by Orchestrating …
X Chen, Y Wu, P Song, L Feng, Y Zhou, J Shi… - Advanced …, 2025 - Wiley Online Library
In situ tissue engineering heart valves (TEHVs) are the most promising way to overcome the
defects of existing valve prostheses. Despite their promising prospects, the clinical …
defects of existing valve prostheses. Despite their promising prospects, the clinical …
Estimation of aortic valve interstitial cell-induced 3D remodeling of poly (ethylene glycol) hydrogel environments using an inverse finite element approach
Aortic valve interstitial cells (AVICs) reside within the leaflet tissues of the aortic valve and
maintain and remodel its extracellular matrix components. Part of this process is a result of …
maintain and remodel its extracellular matrix components. Part of this process is a result of …
[HTML][HTML] The effects of strain history on aortic valve interstitial cell activation in a 3D hydrogel environment
TM West, DP Howsmon, MW Massidda, HN Vo… - APL …, 2023 - pubs.aip.org
Aortic valves (AVs) undergo unique stretch histories that include high rates and magnitudes.
While major differences in deformation patterns have been observed between normal and …
While major differences in deformation patterns have been observed between normal and …
An Inverse Modeling Approach to Estimate Three-Dimensional Aortic Valve Interstitial Cell Stress Fiber Force Levels
Within the aortic valve (AV) leaflet exists a population of interstitial cells (AVICs) that
maintain the constituent tissues by extracellular matrix (ECM) secretion, degradation, and …
maintain the constituent tissues by extracellular matrix (ECM) secretion, degradation, and …
Understanding the fibroblast to myofibroblast activation process using dynamic hydrogels and machine learning
AV Hillsley - 2022 - repositories.lib.utexas.edu
Cardiac fibrosis is a pathological process characterized by excessive tissue deposition,
matrix remodeling, and tissue stiffening. On a cellular level, fibrosis is associated with …
matrix remodeling, and tissue stiffening. On a cellular level, fibrosis is associated with …