Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …
infection and have been suggested to be a useful correlate of protection for vaccine clinical …
[HTML][HTML] Role of the humoral immune response during COVID-19: guilty or not guilty?
M Yaugel-Novoa, T Bourlet, S Paul - Mucosal Immunology, 2022 - Elsevier
Systemic and mucosal humoral immune responses are crucial to fight respiratory viral
infections in the current pandemic of COVID-19 caused by the SARS-CoV-2 virus. During …
infections in the current pandemic of COVID-19 caused by the SARS-CoV-2 virus. During …
Immune correlates analysis of the ENSEMBLE single Ad26. COV2. S dose vaccine efficacy clinical trial
Measuring immune correlates of disease acquisition and protection in the context of a
clinical trial is a prerequisite for improved vaccine design. We analysed binding and …
clinical trial is a prerequisite for improved vaccine design. We analysed binding and …
Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains
Omicron variant strains encode large numbers of changes in the spike protein compared to
historical SARS-CoV-2 isolates. Although in vitro studies have suggested that several …
historical SARS-CoV-2 isolates. Although in vitro studies have suggested that several …
[HTML][HTML] BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with age
Each severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant renews
concerns about decreased vaccine neutralization weakening efficacy. However, while …
concerns about decreased vaccine neutralization weakening efficacy. However, while …
SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals
SI Richardson, VS Madzorera, H Spencer… - Cell Host & Microbe, 2022 - cell.com
Summary The SARS-CoV-2 Omicron variant escapes neutralizing antibodies elicited by
vaccines or infection. However, whether Omicron triggers cross-reactive humoral responses …
vaccines or infection. However, whether Omicron triggers cross-reactive humoral responses …
[HTML][HTML] The Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice
I Ullah, G Beaudoin-Bussières, K Symmes… - Cell Reports …, 2023 - cell.com
Summary COVID-19 convalescent plasmas (CCPs) are chosen for plasma therapy based on
neutralizing titers and anti-Spike immunoglobulin levels. However, CCP characteristics that …
neutralizing titers and anti-Spike immunoglobulin levels. However, CCP characteristics that …
Durability of ChAdOx1 nCoV-19 (AZD1222) vaccine and hybrid humoral immunity against variants including omicron BA. 1 and BA. 4 6 months after vaccination …
Background COVID-19 vaccine rollout is lagging in Africa, where there has been a high rate
of SARS-CoV-2 infection. We aimed to evaluate the effect of SARS-CoV-2 infection before …
of SARS-CoV-2 infection. We aimed to evaluate the effect of SARS-CoV-2 infection before …
Hybrid immunity expands the functional humoral footprint of both mRNA and vector-based SARS-CoV-2 vaccines
Despite the successes of current coronavirus disease 2019 (COVID-19) vaccines, waning
immunity, the emergence of variants of concern, and breakthrough infections among …
immunity, the emergence of variants of concern, and breakthrough infections among …
Impact of antigenic evolution and original antigenic sin on SARS-CoV-2 immunity
M Aguilar-Bretones, RAM Fouchier… - The Journal of …, 2023 - Am Soc Clin Investig
Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and
vaccinations targeting the spike protein (S) offer protective immunity against coronavirus …
vaccinations targeting the spike protein (S) offer protective immunity against coronavirus …