In order to fully understand any complex biochemical system from a mechanistic point of
view, it is necessary to have access to the three-dimensional structures of the molecular …

Human septins comprise a family of 13 genes that encode for> 30 protein isoforms with
ubiquitous and tissue-specific expressions. Septins are GTP-binding proteins that assemble …

Most human cells require anchorage for survival. Cell–substrate adhesion activates diverse
signalling pathways, without which cells undergo anoikis—a form of programmed cell death …

Septins are a family of GTP-binding proteins that assemble into cytoskeletal filaments.
Unlike other cytoskeletal components, septins form ordered arrays of defined stoichiometry …

Septins are GTP-binding proteins that are evolutionarily and structurally related to the RAS
oncogenes. Septin expression levels are altered in many cancers and new advances point …

Peterson EA and Petty EM. Conquering the complex world of human septins: implications for
health and disease. Septins are highly conserved filamentous proteins first characterized in …

Increasing cell mobility is the basis of tumor invasion and metastasis, and is therefore a
therapeutic target for preventing the spread of many types of cancer. Septins are a family of …

This review extensively reports data from the literature concerning the complex relationships
between the stress-induced c-Jun N-terminal kinases (JNKs) and the four main cytoskeleton …

Chronic inflammatory diseases cause profound alterations in tissue homeostasis, including
unchecked activation of immune and nonimmune cells leading to disease complications …

This review article summarizes the research advances of the plasma-based SEPT9 gene
methylation assay for the clinical detection of colorectal cancer and its limitations. Colorectal …