The neurovascular unit (NVU) plays an important role in maintaining the function of the
central nervous system (CNS). Emerging evidence has indicated that the NVU changes …

The intricate nature of Alzheimer's disease (AD) pathogenesis poses a persistent obstacle to
drug development. In recent times, neuroinflammation has emerged as a crucial pathogenic …

Oxidative stress and neuroinflammation have been demonstrated to be linked with
Alzheimer's disease (AD). In this study, we examined the protective effects of DL0410 in …

Our aim was to investigate transitory and delayed exercise effects on serum extracellular
vesicles (EVs) in aging process. Male Wistar rats of 3-, 21-, and 26-month old were allocated …

Oxidative stress and neuroinflammation have been deeply associated with Alzheimer's
disease. DL0410 is a novel acetylcholinesterase inhibitor with potential anti-oxidative effects …

Alzheimer's disease (AD) is a worldwide problem and there are no effective drugs for AD
treatment. Previous studies show that DL0410 is a multi-target, anti-AD agent. In this study …

Bushen-Yizhi prescription (BSYZ) has been an effective traditional Chinese medicine (TCM)
prescription in treating Alzheimer's disease (AD) for hundreds of years. However, the …

Objective Diets rich in quercitrin show a neuroprotective effect, but the mechanism is not
very clear at present. The objective of this study is to explore the effect and mechanism of …

Objective (s) Accumulating evidence has suggested that oxidative stress and apoptosis are
involved in the aging process. d‐galactose (gal) has been reported to cause symptoms of …

Inflammatory reaction in the brain activates glial cells, and over-activated glial cells secrete
inflammatory mediators, which aggravates the inflammatory response in the brain and …