Consistent with well-established biochemical properties of coronaviruses, sialylated glycan
attachments between SARS-CoV-2 spike protein (SP) and host cells are key to the virus's …

Conspectus In nature, proteins range from those with highly ordered secondary and tertiary
structures to those that completely lack a well-defined three-dimensional structure, termed …

Abstract Introduction The PReferentially expressed Antigen in MElanoma (PRAME) protein
has been shown to be an independent biomarker for increased risk of metastasis in Class 1 …

In eukaryotic cells, membrane proteins play a crucial role. They fall into three categories:
intrinsic proteins, extrinsic proteins, and proteins that are essential to the human genome …

Proteostasis, ie, the homeostasis of proteins, responsible for ensuring protein turnover, is
regulated by proteases, which also participate in the etiopathogenesis of multiple conditions …

Proteins are large biomolecules with a specific structure that is composed of one or more
long amino acid chains. Correct protein structures are directly linked to their correct function …

The cysteine-knot containing negative regulator of the Wnt (Wingless-related integration
site) signaling pathway, sclerostin (SOST) is an emerging therapeutic target for …

Motivation Protein structure comparison is pivotal for deriving homological relationships,
elucidating protein functions, and understanding evolutionary developments. The …

Background Understanding how coding genes and their functions evolve over time is a key
aspect of evolutionary biology. Protein coding genes poorly understood or characterized at …

A number of muscular disorders are hallmarked by the aggregation of misfolded proteins
within muscle fibers. A specialized form of macroautophagy, termed aggrephagy, is …