Heme is a complex of iron with protoporphyrin IX that is essential for the function of all
aerobic cells. Heme serves as the prosthetic group of numerous hemoproteins (eg …

Heme (iron protoporphyrin IX) exists as prosthetic group in several hemoproteins, which
include respiration cytochromes, gas sensors, P450 enzymes (CYPs), catalases …

In one form of β-thalassemia, a genetic blood disorder, a mutation in intron 2 of the β-globin
gene (IVS2-654) causes aberrant splicing of β-globin pre-mRNA and, consequently, β …

Since the approval of recombinant insulin from Escherichia coli for its clinical use in the early
1980s, the amount of recombinant pharmaceutical proteins obtained by microbial …

OBJECTIVE: To develop a method to produce in culture large number of erythroid cells from
human embryonic stem cells. MATERIALS AND METHODS: Human H1 embryonic stem …

The term thalassaemia intermedia includes a large spectrum of conditions of varying
severity. Blood transfusion and chelation are necessary in some patients, especially during …

Tal-effector nucleases (TALENs) are engineered proteins that can stimulate precise genome
editing through specific DNA double-strand breaks. Sickle cell disease and β-thalassemia …

Despite considerable concerns with pharmacological stimulation of fetal hemoglobin (Hb F)
as a therapeutic option for the β-globin disorders, the molecular basis of action of Hb F …

The widespread occurrence of intergenic transcription in eukaryotes is increasingly evident.
Intergenic transcription in the β-globin gene cluster has been described in murine and …

With the increasing demand for blood transfusions, the production of human hemoglobin
(Hb) from sustainable sources is increasingly studied. Microbial production is an attractive …