GRP78: A cell's response to stress
Abstract Background Glucose-Regulated Protein 78 (GRP78) is a chaperone heat shock
protein that has been intensely studied in the last two decades. GRP78 is the master of the …
protein that has been intensely studied in the last two decades. GRP78 is the master of the …
[HTML][HTML] Current status of sorafenib nanoparticle delivery systems in the treatment of hepatocellular carcinoma
FH Kong, QF Ye, XY Miao, X Liu, SQ Huang, L Xiong… - Theranostics, 2021 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most common type of liver cancer and one of the
leading causes of cancer-related death worldwide. Advanced HCC displays strong …
leading causes of cancer-related death worldwide. Advanced HCC displays strong …
Mechanism of apoptosis induced by curcumin in colorectal cancer
Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality
rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new …
rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new …
Glucose regulated proteins in cancer progression, drug resistance and immunotherapy
It has been established that as molecular chaperones, the glucose regulated proteins
(GRPs) play an important role in maintaining cellular homeostasis. This conventional …
(GRPs) play an important role in maintaining cellular homeostasis. This conventional …
[HTML][HTML] Endoplasmic reticulum stress associated responses in cancer
The endoplasmic reticulum (ER) is responsible for many housekeeping functions within the
cell and is an important site for pathways that regulates its state of homeostasis. When …
cell and is an important site for pathways that regulates its state of homeostasis. When …
Exosomes derived from siRNA against GRP78 modified bone-marrow-derived mesenchymal stem cells suppress Sorafenib resistance in hepatocellular carcinoma
H Li, C Yang, Y Shi, L Zhao - Journal of nanobiotechnology, 2018 - Springer
Background Sorafenib is an effective clinical drug in therapy of hepatocellular carcinoma,
having led to improved prognosis in hepatocellular carcinoma patients. However acquired …
having led to improved prognosis in hepatocellular carcinoma patients. However acquired …
[HTML][HTML] Safety and activity of IT-139, a ruthenium-based compound, in patients with advanced solid tumours: A first-in-human, open-label, dose-escalation phase I …
HA Burris, S Bakewell, JC Bendell, J Infante, SF Jones… - ESMO open, 2016 - Elsevier
Objective This phase I clinical study (NCT01415297) evaluated the safety, tolerability,
maximum-tolerated dose (MTD), pharmacokinetics and pharmacodynamics of IT-139 …
maximum-tolerated dose (MTD), pharmacokinetics and pharmacodynamics of IT-139 …
Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives
Cellular stress induced by the accumulation of misfolded proteins at the endoplasmic
reticulum (ER) is a central feature of secretory cells and is observed in many tissues in …
reticulum (ER) is a central feature of secretory cells and is observed in many tissues in …
ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining “stemness”
Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) signaling have
been shown to be dysregulated in multiple cancer types. Glucose regulatory protein 78 …
been shown to be dysregulated in multiple cancer types. Glucose regulatory protein 78 …
Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach
H Xue, B Lü, J Zhang, M Wu, Q Huang… - Journal of proteome …, 2010 - ACS Publications
Lymph node metastasis is the major concern that causes death in colorectal cancers.
However, biomarkers for cancer metastasis are still lacking. In this study, we applied an LC …
However, biomarkers for cancer metastasis are still lacking. In this study, we applied an LC …