Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …

Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

Antibacterial autophagy (xenophagy) is an important host defense, but how it is initiated is
unclear. Here, we performed a bacterial transposon screen and identified a T3SS effector …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Objective The protein post-translational modification (PTM) in host cells can be rewritten by
bacterial enzymes and represents an unprecedented mechanism in the communication …

Following phagocytosis, the nascent phagosome undergoes maturation to become a
phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill …

Protein lipidation dramatically affects protein structure, localization, and trafficking via
remodeling protein–membrane and protein–protein interactions through hydrophobic lipid …

Selective autophagy helps eukaryotes to cope with endogenous dangers or foreign
invaders; its initiation often involves membrane damage. By studying a Salmonella effector …

Shigella spp. are diarrheal pathogens closely related to Escherichia coli. They are named
after Kiyoshi Shiga, who in 1898 identified its most virulent member, Shigella dysenteriae, as …

Lysine fatty acylation in mammalian cells was discovered nearly three decades ago, yet the
enzymes catalyzing it remain unknown. Unexpectedly, we find that human N-terminal …