WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Given its chronicity, contribution to disability and morbidity, and prevalence of more than 2%,
the effective treatment, and prevention of bipolar disorder represents an area of significant …

Summary Wnt ligands oligomerize Frizzled (Fzd) and Lrp5/6 receptors to control the
specification and activity of stem cells in many species. How Wnt signaling is selectively …

The human genome functions as a three-dimensional chromatin polymer, driven by a
complex collection of chromosome interactions,–. Although the molecular rules governing …

Wnt signaling pathways have been extensively studied in the context of several diseases,
including cancer, coronary artery disease, and age-related disorders. β-Catenin plays a …

The principle steroidal androgens are testosterone and its metabolite 5α-
dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α …

Background Structural birth defects occur in approximately 3% of live births; most such
defects lack defined genetic or environmental causes. Despite advances in surgical …

Cardiac differentiation efficiency is hampered by inconsistencies and low reproducibility. We
analyzed the differentiation process of multiple human pluripotent stem cell (hPSC) lines in …

The discovery and application of small molecules is one of the practical strategies of safe
osteogenic drugs. The small molecule CHIR99021 (C91) is a highly specific, safe, and most …

While the genetic basis of schizophrenia is increasingly well characterized, novel treatments
will require establishing mechanistic relationships between specific risk genes and core …