Gasdermins were recently identified as the mediators of pyroptosis—inflammatory cell death
triggered by cytosolic sensing of invasive infection and danger signals. Upon activation …

Cell death is an essential process in all living organisms and occurs through different
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …

Canonically, gasdermin D (GSDMD) cleavage by caspase-1 through inflammasome
signaling triggers immune cell pyroptosis (ICP) as a host defense against pathogen …

Gasdermins are a family of structurally related proteins originally described for their role in
pyroptosis. Gasdermin B (GSDMB) is currently the least studied, and while its association …

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths in the world.
Inflammation is often an underlying risk factor for developing CRC. Maintaining gut …

Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important
self-protection mechanisms against stimuli and infections. Hosts can defend against …

The intestinal epithelial cells (IECs) constitute the primary barrier between host cells and
numerous foreign antigens; it is unclear how IECs induce the protective immunity against …

Cellular inflammasome activation causes caspase-1 cleavage of the pore-forming protein
gasdermin D (GSDMD) with subsequent pyroptotic cell death and cytokine release. Here …

Since the identification and characterization of gasdermin (GSDM) D as the main effector of
inflammatory regulated cell death (or pyroptosis), literature on the GSDM family of pore …

Gasdermin D (GSDMD) serves as a key executor to trigger pyroptosis and is emerging as an
attractive checkpoint in host defense, inflammatory, autoimmune diseases, and many other …