Background Although outcomes of patients after cardiac arrest remain poor, studies have
suggested that extracorporeal cardiopulmonary resuscitation (ECPR) might improve survival …

To inform evidence-based practice in health care, guidelines and policies require accurate
identification, collation, and integration of all available evidence in a comprehensive …

Background: The MiniMed™ 780G system includes an advanced hybrid closed loop (AHCL)
algorithm that provides both automated basal and correction bolus insulin delivery. The …

Nonrandomized observational analyses of large electronic patient databases are being
promoted as an alternative to randomized clinical trials as a source of “real-world evidence” …

Protocols of systematic reviews and meta-analyses allow for planning and documentation of
review methods, act as a guard against arbitrary decision making during review conduct …

Objectives To compare re-rupture rate, complication rate, and functional outcome after
operative versus nonoperative treatment of Achilles tendon ruptures; to compare re-rupture …

Purpose The Medical Education Research Study Quality Instrument (MERSQI) and the
Newcastle–Ottawa Scale-Education (NOS-E) were developed to appraise methodological …

Background: Regulators are evaluating the use of noninterventional real-world evidence
(RWE) studies to assess the effectiveness of medical products. The RCT DUPLICATE …

Background: The best type of autograft for anterior cruciate ligament (ACL) reconstruction
remains debatable. Hypothesis: Compared with bone–patellar tendon–bone (BPTB) and …

Background Thresholds for statistical significance when assessing meta-analysis results are
being insufficiently demonstrated by traditional 95% confidence intervals and P-values …