The human genome encodes 538 protein kinases that transfer a γ-phosphate group from
ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with …

Aurora kinases are serine/threonine kinases essential for the onset and progression of
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …

The Aurora kinase family is comprised of three serine/threonine kinases, Aurora‐A, Aurora‐
B, and Aurora‐C. Among these, Aurora‐A and Aurora‐B play central roles in mitosis …

Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …

Gene dosage variations occur in many diseases. In cancer, deletions and copy number
increases contribute to alterations in the expression of tumour-suppressor genes and …

Genetic and biochemical studies in lower eukaryotes have identified several proteins that
ensure accurate segregation of chromosomes. These include the Drosophila aurora and …

The centrosomes are thought to maintain genomic stability through the establishment of
bipolar spindles during cell division, ensuring equal segregation of replicated chromosomes …

Defects in cell-death pathways are hallmarks of cancer. Although resistance to apoptosis is
closely linked to tumorigenesis, tumour cells can still be induced to die by non-apoptotic …

Despite the worldwide public health impact of malaria, neither the mechanism by which the
Plasmodium parasite detoxifies and sequesters haem, nor the action of current antimalarial …

Gene amplifications and deletions frequently contribute to tumorigenesis. Characterization
of these DNA copy-number changes is important for both the basic understanding of cancer …