Duchenne muscular dystrophy (DMD) is caused by the lack of functional dystrophin protein.
Improvements in patient care and disease management have slowed down disease …

Duchenne muscular dystrophy (DMD) is a monogenic muscle-wasting disorder and a
priority candidate for molecular and cellular therapeutics. Although rare, it is the most …

Duchenne muscular dystrophy is an X-linked disease caused by the absence of functional
dystrophin in the muscle cells. Major advances have led to the development of gene …

Despite many reports of putative stem-cell-based treatments in genetic and degenerative
disorders or severe injuries, the number of proven stem cell therapies has remained small …

Stem-Cell Research and Clinical Application Stem cells have been the focus of hope, hype,
and a great deal of research. But what exactly is a stem cell, and what are its uses? This …

Executive summary In this Commission, we argue that a combination of poor quality science,
unclear funding models, unrealistic hopes, and unscrupulous private clinics threatens …

Satellite cells are tissue resident muscle stem cells required for postnatal skeletal muscle
growth and repair through replacement of damaged myofibers. Muscle regeneration is …

One of the most fascinating questions in regenerative biology is why some animals can
regenerate injured structures while others cannot. Skeletal muscle has a remarkable …

Muscular dystrophies are a heterogeneous group of genetic diseases, characterized by
progressive degeneration of skeletal and cardiac muscle. Despite the intense investigation …

The peculiar ability of skeletal muscle tissue to operate adaptive changes during post-natal
development and adulthood has been associated with the existence of adult somatic stem …