Many drug–drug interactions (DDI s) are based on alterations of the plasma concentrations
of a victim drug due to another drug causing inhibition and/or induction of the metabolism or …

Typically, therapeutic proteins (TPs) have a low risk for eliciting meaningful drug interactions
(DIs). However, there are select instances where TP drug interactions (TP‐DIs) of clinical …

Hospitalized pediatric patients and those with complex or chronic conditions treated on an
outpatient basis are commonly prescribed multiple drugs, resulting in increased risk for drug …

The current regulatory path for new drug registration in East Asian countries has led to
significant delay of the new medicines in these countries. A unified regulatory path and …

Patients with cancer and advanced hepatic impairment (HI)(ie, moderate and severe
impairment) are often excluded from first‐in‐patient, phase II, and phase III studies. Thus …

Rutin is the rutinose conjugate of quercetin. It presents several biological activities and is the
major flavonoid in the hydroalcoholic extract of the calyces of Physalis peruviana L. It also …

None of the physiologically based pharmacokinetic (PBPK) approaches using preclinical
data show high predictability of human pharmacokinetic (PK) profiles for drugs affected by …

P< 0.05), MPA 와 대사체의 약동력학 파라미터는 유의미한 변화를 보이지 않았다. TAC 의
청소율은 MMF 와 병용하지 않았을 때에는 17.8 L/h (상대표준오차 11%) 였고, MMF 와 …