Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders

S Ducharme, A Dols, R Laforce, E Devenney, F Kumfor… - Brain, 2020 - academic.oup.com
The behavioural variant of frontotemporal dementia (bvFTD) is a frequent cause of early-
onset dementia. The diagnosis of bvFTD remains challenging because of the limited …

Early-onset Alzheimer disease and its variants

MF Mendez - CONTINUUM: Lifelong Learning in Neurology, 2019 - journals.lww.com
PURPOSE OF REVIEW Early-onset Alzheimer disease (AD) is defined as having an age of
onset younger than 65 years. While early-onset AD is often overshadowed by the more …

Global prevalence of young-onset dementia: a systematic review and meta-analysis

S Hendriks, K Peetoom, C Bakker… - JAMA …, 2021 - jamanetwork.com
Importance Reliable prevalence estimates are lacking for young-onset dementia (YOD), in
which symptoms of dementia start before the age of 65 years. Such estimates are needed for …

Anticholinergic drug exposure and the risk of dementia: a nested case-control study

CAC Coupland, T Hill, T Dening, R Morriss… - JAMA internal …, 2019 - jamanetwork.com
Importance Anticholinergic medicines have short-term cognitive adverse effects, but it is
uncertain whether long-term use of these drugs is associated with an increased risk of …

AlzheimerNet: An effective deep learning based proposition for alzheimer's disease stages classification from functional brain changes in magnetic resonance images

FMJM Shamrat, S Akter, S Azam, A Karim… - IEEE …, 2023 - ieeexplore.ieee.org
Alzheimer's disease is largely the underlying cause of dementia due to its progressive
neurodegenerative nature among the elderly. The disease can be divided into five stages …

Early-onset Alzheimer disease

MF Mendez - Neurologic clinics, 2017 - neurologic.theclinics.com
Alzheimer disease (AD) originally meant a disorder of early-onset (EOAD;< 65 years of age)
and did not include older patients with “senile dementia.” In fact, the first patient reported …

Cross-cohort generalizability of deep and conventional machine learning for MRI-based diagnosis and prediction of Alzheimer's disease

EE Bron, S Klein, JM Papma, LC Jiskoot… - NeuroImage: Clinical, 2021 - Elsevier
This work validates the generalizability of MRI-based classification of Alzheimer's disease
(AD) patients and controls (CN) to an external data set and to the task of prediction of …

Risk factors for young-onset dementia in the UK Biobank

S Hendriks, JM Ranson, K Peetoom, I Lourida… - JAMA …, 2024 - jamanetwork.com
Importance There is limited information on modifiable risk factors for young-onset dementia
(YOD). Objective To examine factors that are associated with the incidence of YOD. Design …

The impact of early dementia diagnosis and intervention on informal caregivers

ME De Vugt, FRJ Verhey - Progress in neurobiology, 2013 - Elsevier
In the absence of disease modifying therapies for dementia, the question rises what the
benefits are of an early dementia diagnosis for patients and their caregivers. This paper …

Time to diagnosis in young‐onset dementia and its determinants: the INSPIRED study

B Draper, M Cations, F White, J Trollor… - … journal of geriatric …, 2016 - Wiley Online Library
Objective The objective of this study is to identify factors determining the time to diagnosis for
young‐onset dementia (YOD), defined as dementia with symptom onset before age 65 …