The role of interleukin-8 in lung inflammation and injury: implications for the management of COVID-19 and hyperinflammatory acute respiratory distress syndrome

MC Cesta, M Zippoli, C Marsiglia, EM Gavioli… - Frontiers in …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus—2 (SARS CoV-2) has resulted in the
global spread of Coronavirus Disease 2019 (COVID-19) and an increase in complications …

Pathophysiology of COVID-19: critical role of hemostasis

SA Andrade, DA de Souza, AL Torres… - Frontiers in cellular …, 2022 - frontiersin.org
The COVID-19 pandemic, caused by SARS-CoV-2, had its first cases identified in late 2019
and was considered a clinical pandemic in March 2020. In March 2022, more than 500 …

[HTML][HTML] Impaired immune response drives age-dependent severity of COVID-19

J Beer, S Crotta, A Breithaupt, A Ohnemus… - Journal of Experimental …, 2022 - rupress.org
Severity of COVID-19 shows an extraordinary correlation with increasing age. We generated
a mouse model for severe COVID-19 and show that the age-dependent disease severity is …

SARS-CoV-2-infection (COVID-19): clinical course, viral acute respiratory distress syndrome (ARDS) and cause (s) of death

GP Ramadori - Medical Sciences, 2022 - mdpi.com
SARS-CoV-2-infected symptomatic patients often suffer from high fever and loss of appetite
which are responsible for the deficit of fluids and of protein intake. Many patients admitted to …

New insights into clinical and mechanistic heterogeneity of the acute respiratory distress syndrome: summary of the Aspen Lung Conference 2021

TR Martin, RL Zemans, LB Ware… - American journal of …, 2022 - atsjournals.org
Clinical and molecular heterogeneity are common features of human disease.
Understanding the basis for heterogeneity has led to major advances in therapy for many …

Open questions in cold atmospheric plasma treatment in head and neck cancer: a systematic review

V Perrotti, VCA Caponio, LL Muzio, EH Choi… - International Journal of …, 2022 - mdpi.com
Over the past decade, we witnessed a promising application of cold atmospheric plasma
(CAP) in cancer therapy. The aim of this systematic review was to provide an exhaustive …

Pyronaridine protects against SARS-CoV-2 infection in mouse

AC Puhl, GF Gomes, S Damasceno… - ACS Infectious …, 2022 - ACS Publications
There are currently relatively few small-molecule antiviral drugs that are either approved or
emergency-approved for use against severe acute respiratory coronavirus 2 (SARS-CoV-2) …

[HTML][HTML] Impact of P-selectin–PSGL-1 Axis on Platelet-Endothelium-Leukocyte Interactions in Fatal COVID-19

M Granai, V Warm, A Vogelsberg, J Milla, K Greif… - Laboratory …, 2023 - Elsevier
In critically ill patients infected with SARS-CoV-2, early leukocyte recruitment to the
respiratory system was found to be orchestrated by leukocyte trafficking molecules …

Predictors for COVID-19 complete remission with HRCT pattern evolution: a monocentric, prospective study

D Manolescu, B Timar, F Bratosin, O Rosca, C Citu… - Diagnostics, 2022 - mdpi.com
There are growing concerns that some COVID-19 survivors may acquire fibrosis and other
irreversible lung abnormalities. The purpose of this prospective study was to assess the rate …

The hidden pandemic of COVID-19-induced organizing pneumonia

E Bazdyrev, M Panova, V Zherebtsova, A Burdenkova… - Pharmaceuticals, 2022 - mdpi.com
Since the beginning of the COVID-19 pandemic, clinical, radiological, and histopathological
studies have provided evidence that organizing pneumonia is a possible consequence of …