Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Lysosomes have been classically considered terminal degradative organelles, but in recent
years they have been found to participate in many other cellular processes, including killing …

Since the discovery of lysosomes more than 70 years ago, much has been learned about
the functions of these organelles. Lysosomes were regarded as exclusively degradative …

Alzheimer′ s disease (AD) is the most common type of dementia. In connection with the
global trend of prolonging human life and the increasing number of elderly in the population …

▪ Abstract Phagocytosis of pathogens by macrophages initiates the innate immune
response, which in turn orchestrates the adaptive response. In order to discriminate between …

Late endosomes (LEs) have characteristic intracellular distributions determined by their
interactions with various motor proteins. Motor proteins associated to the dynactin subunit …

Cells transport and sort proteins and lipids, after their synthesis, to various destinations at
appropriate velocities in membranous organelles and protein complexes. Intracellular …

The multiple functions of lysosomes are critically dependent on their ability to undergo
bidirectional movement along microtubules between the center and the periphery of the cell …

The small GTPase ARL8 associates with endolysosomes, leading to the recruitment of
several effectors that couple endolysosomes to kinesins for anterograde transport along …

Since the first published examination of poly (ethylenimine)(PEI) as a gene delivery vehicle,
there has been a flurry of research aimed at this polycation and its role in gene therapy …