Immunogenic cell death (ICD) is a regulated cell death (RCD) pathway. In response to
physical and chemical signals, tumor cells activate specific signaling pathways that stimulate …

Cardiac glycosides (CGs) have a long history of treating cardiac diseases. However, recent
reports have suggested that CGs also possess anticancer and antiviral activities. The …

Cardiac glycosides (CGs) are a diverse family of naturally derived compounds having a
steroid and glycone moiety in their structures. CG molecules inhibit the α-subunit of …

Background Aberrant activation of STAT3 is frequently encountered and promotes survival,
cellular proliferation, migration, invasion and angiogenesis in tumor cell. Convallatoxin …

Metastasis is the main cause of death in patients with cancer. The molecular mechanisms
underlying the different metastasis steps are not yet fully known, partly because most studies …

Ion homeostasis is extremely important for the survival of both normal as well as neoplastic
cells. The altered ion homeostasis found in cancer cells prompted the investigation of …

Active metabolites from natural sources are the predominant molecular targets in numerous
biological studies owing to their appropriate compatibility with biological systems and …

Aim To investigate the cytotoxic effect of Peruvoside and mechanism of action in human
cancers. Main methods Cell viability was measured by MTT assay and the cell cycle arrest …

Cardiac glycosides are plant-derived steroid-like compounds which have been used for the
treatment of cardiovascular diseases. Ouabain, a cardiotonic steroid and specific Na+/K+ …

Lung cancer is the most prevalent in cancer-related deaths, while breast carcinoma is the
second most dominant cancer in women, accounting for the most number of deaths …