Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

Regeneration is the process by which organisms replace lost or damaged tissue, and
regenerative capacity can vary greatly among species, tissues and life stages. Tissue …

Every animal grows from a single fertilized egg into an intricate network of cell types and
organ systems. This process is captured in a lineage tree: a diagram of every cell's ancestry …

Immediately after cardiac injury, the immune system plays major roles in repair and
regeneration as it becomes involved in a number of processes including damage …

The majority of animal phyla have species that can regenerate. Comparing regeneration
across animals can reconstruct the molecular and cellular evolutionary history of this …

The peripheral nervous system has retained through evolution the capacity to repair and
regenerate after assault from a variety of physical, chemical, or biological pathogens …

Background Zebrafish can faithfully regenerate injured fins through the formation of a
blastema, a mass of proliferative cells that can grow and develop into the lost body part. After …

Hair follicles are mini organs that repeat the growth and regression cycle continuously.
These dynamic changes are driven by the regulation of stem cells via their multiple niche …

Zebrafish can regenerate their damaged hearts throughout their lifespan. It is, however,
unknown, whether regeneration remains effective when challenged with successive cycles …

Adult zebrafish are widely used to interrogate mechanisms of disease development and
tissue regeneration. Yet, the prospect of large-scale genetics in adult zebrafish has …