Highlights•The buccal route has been exploited for selected potent small
molecules.•Research to achieve buccal insulin delivery is based on avoiding the …

Bacterial endophthalmitis (BE) is a potentially sight-threatening inflammatory reaction of the
intraocular fluids or tissues caused by bacteria. Ciprofloxacin (CIP) eye drops are prescribed …

There are several routes of drug administration, and each one has advantages and
limitations. In the case of the topical application in the oral cavity, comprising the buccal …

Purpose: Zaleplon (ZL) is a hypnotic drug prescribed for the management of insomnia and
convulsions. The oral bioavailability of ZL was low (∼ 30%) owing to poor water solubility …

The aim of the proposed work was to develop robust hot-melt extrusion (HME) process for
fabricating sustained-release mini-matrices (pellets) of a highly water-soluble drug, tramadol …

This article describes the current state and future perspectives of solid lipid nanoparticles for
achieving high delivery of drugs with greater therapeutic outcomes. The oral route is the …

Resveratrol, a phytoalexin from grapes, has shown several therapeutic benefits such as anti-
inflammatory and chemopreventive effects. There is a need to develop novel methods for …

Pellets are spherical shaped multiparticulate drug delivery systems with size ranging
between 0.5‐2.0 mm. Free flow, good mechanical properties, improved physical and …

The use of hot-melt extrusion (HME) technique in the preparation of semi-solid products
offers several advantages over conventional processes. However, the optimization of the …

Duloxetine hydrochloride is a selective serotonin and nor adrenaline reuptake inhibitor. It is
used in the treatment of depression, diabetic peripheral neuropathic pain and in moderate to …