Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics

AM Jaster, J González-Maeso - Molecular psychiatry, 2023 - nature.com
Psychedelics, also known as classical hallucinogens, have been investigated for decades
due to their potential therapeutic effects in the treatment of neuropsychiatric and substance …

Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants

W Duan, D Cao, S Wang, J Cheng - Chemical Reviews, 2023 - ACS Publications
Psychedelics make up a group of psychoactive compounds that induce hallucinogenic
effects by activating the serotonin 2A receptor (5-HT2AR). Clinical trials have demonstrated …

Psychedelics reopen the social reward learning critical period

R Nardou, E Sawyer, YJ Song, M Wilkinson… - Nature, 2023 - nature.com
Psychedelics are a broad class of drugs defined by their ability to induce an altered state of
consciousness,. These drugs have been used for millennia in both spiritual and medicinal …

G protein–coupled receptor signaling: new insights define cellular nanodomains

MJ Lohse, A Bock, M Zaccolo - Annual Review of Pharmacology …, 2024 - annualreviews.org
G protein–coupled receptors are the largest and pharmacologically most important receptor
family and are involved in the regulation of most cell functions. Most of them reside …

Accelerated TMS-moving quickly into the future of depression treatment

SJH Van Rooij, AR Arulpragasam… - …, 2024 - nature.com
Accelerated TMS is an emerging application of Transcranial Magnetic Stimulation (TMS)
aimed to reduce treatment length and improve response time. Extant literature generally …

Beyond the 5-HT2A receptor: classic and nonclassic targets in psychedelic drug action

LP Cameron, J Benetatos, V Lewis… - Journal of …, 2023 - Soc Neuroscience
Serotonergic psychedelics, such as psilocybin and LSD, have garnered significant attention
in recent years for their potential therapeutic effects and unique mechanisms of action …

Psychedelics as transformative therapeutics

BL Roth, RH Gumpper - American Journal of Psychiatry, 2023 - Am Psychiatric Assoc
Over the past decade, psychedelic compounds have emerged as potentially transformative
therapeutics for a variety of intractable neuropsychiatric conditions. However, historically …

Therapeutic mechanisms of psychedelics and entactogens

BD Heifets, DE Olson - Neuropsychopharmacology, 2024 - nature.com
Recent clinical and preclinical evidence suggests that psychedelics and entactogens may
produce both rapid and sustained therapeutic effects across several indications. Currently …

The role of neurotrophic factors in novel, rapid psychiatric treatments

J Kim, MJ He, AK Widmann, FS Lee - Neuropsychopharmacology, 2024 - nature.com
Neurotrophic factors are a family of growth factors that modulate cellular growth, survival,
and differentiation. For many decades, it has been generally believed that a lack of …

Different hierarchical reconfigurations in the brain by psilocybin and escitalopram for depression

G Deco, Y Sanz Perl, S Johnson, N Bourke… - Nature Mental …, 2024 - nature.com
Effective interventions for neuropsychiatric disorders may work by rebalancing the brain's
functional hierarchical organization. Here we directly investigated the effects of two different …