Retinal vasculature development in health and disease

S Selvam, T Kumar, M Fruttiger - Progress in retinal and eye research, 2018 - Elsevier
Abstract Development of the retinal vasculature is based on highly coordinated signalling
between different cell types of the retina, integrating internal metabolic requirements with …

[HTML][HTML] Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives

R Simo, C Hernández - Trends in Endocrinology & Metabolism, 2014 - cell.com
Diabetic retinopathy (DR), one of the leading causes of preventable blindness, has been
considered a microcirculatory disease of the retina. However, there is emerging evidence to …

[HTML][HTML] Classification of diabetic retinopathy: Past, present and future

Z Yang, TE Tan, Y Shao, TY Wong, X Li - Frontiers in Endocrinology, 2022 - frontiersin.org
Diabetic retinopathy (DR) is a leading cause of visual impairment and blindness worldwide.
Since DR was first recognized as an important complication of diabetes, there have been …

[HTML][HTML] Animal models of diabetic retinopathy

AM Olivares, K Althoff, GF Chen, S Wu… - Current diabetes …, 2017 - Springer
Abstract Purpose of Review Diabetic retinopathy (DR) is one of the most common
complications associated with chronic hyperglycemia seen in patients with diabetes mellitus …

Animal models of diabetic retinopathy: summary and comparison

AKW Lai, ACY Lo - Journal of diabetes research, 2013 - Wiley Online Library
Diabetic retinopathy (DR) is a microvascular complication associated with chronic exposure
to hyperglycemia and is a major cause of blindness worldwide. Although clinical …

[HTML][HTML] Many faces of renin-angiotensin system-focus on eye

M Holappa, H Vapaatalo… - The open ophthalmology …, 2017 - ncbi.nlm.nih.gov
The renin-angiotensin system (RAS), that is known for its role in the regulation of blood
pressure as well as in fluid and electrolyte homeostasis, comprises dozens of angiotensin …

[HTML][HTML] Diabetic retinopathy: from animal models to cellular signaling

PM Pitale, MS Gorbatyuk - International Journal of Molecular Sciences, 2022 - mdpi.com
Diabetic retinopathy (DR) is an ocular complication of diabetes mellitus (DM), a metabolic
disorder characterized by elevation in blood glucose level. The pathogenesis of DR includes …

[HTML][HTML] Diabetic retinal neurodegeneration as a form of diabetic retinopathy

D Soni, P Sagar, B Takkar - International Ophthalmology, 2021 - Springer
Purpose To review the evidence supporting diabetic retinal neurodegeneration (DRN) as a
form of diabetic retinopathy. Method Review of literature. Results DRN is recognized to be a …

[HTML][HTML] Neurodegeneration: an early event of diabetic retinopathy

M Villarroel, A Ciudin, C Hernández… - World journal of …, 2010 - ncbi.nlm.nih.gov
Diabetic retinopathy (DR) has been classically considered to be a microcirculatory disease
of the retina caused by the deleterious metabolic effects of hyperglycemia per se and the …

[HTML][HTML] Oxygen-induced retinopathy: a model for vascular pathology in the retina

A Scott, M Fruttiger - Eye, 2010 - nature.com
Ischaemic vascular disease in the retina may either leave retina permanently ischaemic with
slow degradation of vision, or alternatively lead to proliferative vascular disease, which can …