Mitochondrial DNA (mtDNA) faces the universal challenges of genome maintenance: the
accurate replication, transmission and preservation of its integrity throughout the life of the …

Plant mitochondria have a complex and peculiar genetic system. They have the largest
genomes, as compared to organelles from other eukaryotic organisms. These can expand …

Pathogenic mitochondrial DNA (mtDNA) mutations can cause a variety of human diseases.
The recent development of genome-editing technologies to manipulate mtDNA, such as …

Both endogenous processes and exogenous physical and chemical sources generate
deoxyribonucleic acid (DNA) damage in the nucleus and organelles of living cells. To …

Participating in the repair of nuclear DNA is one mechanism by which p53 suppresses
tumorigenesis, but there is growing evidence that p53 also helps maintain the mitochondrial …

The mitochondrial DNA (mtDNA) encodes for only 13 polypeptides, components of 4 of the 5
oxidative phosphorylation complexes. But despite this apparently small numeric …

Aging and oxidative stress seem to be the most important factors in the pathogenesis of age-
related macular degeneration (AMD), a condition affecting many elderly people in the …

During the last decades, our knowledge about the processes involved in the aging process
has exponentially increased. However, further investigation will be still required to globally …

Abstract Ribosomal protein S3 (rpS3) is known to play critical roles in ribosome biogenesis
and DNA repair. When cellular ROS levels increase, the mitochondrial genes are highly …

The mitochondrial genome exists in numerous structural conformations, complicating the
study of mitochondrial DNA (mtDNA) metabolism. Here, we describe the development of 2D …