Tissue penetration of antimicrobials in intensive care unit patients: a systematic review—part I

S Finazzi, G Luci, C Olivieri, M Langer, G Mandelli… - Antibiotics, 2022 - mdpi.com
The challenging severity of some infections, especially in critically ill patients, makes the
diffusion of antimicrobial drugs within tissues one of the cornerstones of chemotherapy. The …

An evaluation of the potential of essential oils against SARS-CoV-2 from in silico studies through the systematic review using a chemometric approach

L Torres Neto, MLG Monteiro, D Galvan… - Pharmaceuticals, 2021 - mdpi.com
Essential oils (EOs) and their compounds have attracted particular attention for their
reported beneficial properties, especially their antiviral potential. However, data regarding …

Population pharmacokinetics of colistin sulfate in critically ill patients: exposure and clinical efficacy

X Yu, XS Zhang, YX Wang, YZ Wang… - Frontiers in …, 2022 - frontiersin.org
Background: Presently, colistin is commercially available in two different forms, namely,
colistin sulfate and its sulphomethylated derivative, colistimethate sodium (CMS). However …

Population Pharmacokinetic Analysis and Dosing Optimization of Colistin Sulfate in Lung Transplant Recipients with Pneumonia: A Prospective Study

X Cai, Y Chen, J Fu, Y Chen, L Shi, C Chen… - International Journal of …, 2024 - Elsevier
Objectives Currently, there is a lack of information on the clinical pharmacokinetics (PK),
effectiveness, and safety of colistin sulfate in lung transplant recipients. This study aims to …

Advances in the clinical treatment of multidrug-resistant pathogens using polymyxins

Y Huang, M Liao, X Hu, H Hu… - Journal of Antimicrobial …, 2024 - academic.oup.com
Objectives Polymyxins are a vital class of antibiotics used to combat multidrug-resistant
Gram-negative bacteria. However, their use is limited due to potential nephrotoxicity and the …

Impact of clinical pharmacist's interventions on clinical outcomes in appropriate use of Colistin: a prospective pre-post intervention study

A Albayrak, HS Özger, B Başgut… - Journal of …, 2023 - Taylor & Francis
This study aims to evaluate the clinical pharmacist's contribution impact on the appropriate
use of colistin. Our study was conducted prospectively in patients in the Internal Diseases …

Indian consensus on the managemeNt of carbapenem-resistant enterobacterales infection in critically ill patients II (ICONIC II)

R Soman, B Veeraraghavan, A Hegde… - Expert Review of Anti …, 2024 - Taylor & Francis
Introduction The rising challenge of carbapenem-resistant Enterobacterales (CRE)
infections in Indian healthcare settings calls for clear clinical guidance on the management …

[HTML][HTML] Understanding antimicrobial pharmacokinetics in critically ill patients to optimize antimicrobial therapy: A narrative review

C Roger - Journal of Intensive Medicine, 2024 - Elsevier
Effective treatment of sepsis not only demands prompt administration of appropriate
antimicrobials but also requires precise dosing to enhance the likelihood of patient survival …

New Predictive Equation for the Estimation of Plasma Concentrations of Formed Colistin in Patients Treated With Colistimethate Sodium for Multidrug-Resistant Gram …

S Luque, L Sorlí, J Li, X Fernández-Sala… - Therapeutic Drug …, 2024 - journals.lww.com
Background: The clinical use of colistin methanesulphonate (CMS) is limited by potential
nephrotoxicity. The selection of an efficient and safe CMS dose for individual patients is …

Diclofenac sensitizes multi-drug resistant Acinetobacter baumannii to colistin

F Bisaro, CD Jackson-Litteken, JC McGuffey… - bioRxiv, 2024 - biorxiv.org
Acinetobacter baumannii causes life-threatening infections that are becoming difficult to treat
due to increasing rates of multi-drug resistance (MDR) among clinical isolates. This has led …