Increases in calorie consumption and sedentary lifestyles are fuelling a global pandemic of
cardiometabolic diseases, including coronary artery disease, diabetes mellitus …

Reactive oxygen species (ROS) are reactive intermediates of molecular oxygen that act as
important second messengers within the cells; however, an imbalance between generation …

Oxidative stress plays a pivotal role in the development of diabetes complications, both
microvascular and cardiovascular. The metabolic abnormalities of diabetes cause …

Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Hydroethidine (HE; or dihydroethidium) is the most popular fluorogenic probe used for
detecting intracellular superoxide radical anion. The reaction between superoxide and HE …

Glial activation participates in the mediation of pain including neuropathic pain, due to
release of neuroexcitatory, proinflammatory products. Glial activation is now known to occur …

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Vascular dysfunction that accompanies obesity and insulin resistance may be mediated by
lipid metabolites. We sought to determine if vascular ceramide leads to arterial dysfunction …

Obesity-induced adipose dysfunction is a major contributor to atherosclerosis. Cold
exposure has been reported to affect atherosclerosis through regulation of adipose function …

Activation of cells by receptor-and nonreceptor-mediated stimuli not only requires a change
in the activity of signaling proteins but also requires a reorganization of the topology of the …