Mushrooms have been used extensively, owing to their nutritional and medicinal value, for
thousands of years. Modern research confirms the therapeutic effect of traditionally used …

Induction of autophagy is a prospective approach to the treatment of neurodegeneration. In
the recent decade, trehalose attracted special attention. It is an autophagy inducer with …

Exosomes are important mediators in intercellular communication. Released by many cell
types, they transport proteins, lipids, and nucleic acids to distant recipient cells and …

Background: Trehalose (TRE) is a natural, nonreducing disaccharide synthesized by lower
organisms. TRE exhibits an extraordinary ability to protect cells against different kinds of …

The application of exosomes as a therapeutic reagent or drug delivery vehicle can be
expanded by developing a method to preserve exosomes. Although exosomes are …

Early brain injury (EBI), highlighted with inflammation and apoptosis, occurring within 72 h
after subarachnoid hemorrhage (SAH), is associated with the prognosis of SAH. Recent …

Parkinson's disease (PD) is a progressive movement disorder resulting primarily from loss of
nigrostriatal dopaminergic neurons. PD is characterized by the accumulation of protein …

The accumulation of misfolded α-synuclein in dopamine (DA) neurons is believed to be of
major importance in the pathogenesis of Parkinson's disease (PD). Animal models of PD …

Within the group of higher fungi, edible medicinal mushrooms have a long history of being
used as food and in folk medicine. These species contain biologically active substances with …

Cadmium (Cd) is a persistent environmental contaminant and induces neurotoxicity in
animals. Trehalose (Tre) exhibits powerful neuroprotective effects in certain brain injury …