Neurodegenerative diseases (NDDs) are characterized by selective dysfunction and loss of
neurons associated with pathologically altered proteins that deposit in the human brain but …

Abnormal prion proteins are responsible for several fatal neurodegenerative diseases in
humans and in animals, including Creutzfeldt–Jakob disease (CJD), Gerstmann–Sträussler …

Dementia with Lewy bodies (DLB), Parkinson's disease (PD) and multiple system atrophy
are characterized by the deposition of disease-associated α-synuclein. In the present study …

The current classification of sporadic Creutzfeldt–Jakob disease (sCJD) includes six major
clinicopathological subtypes defined by the physicochemical properties of the protease …

Abstract Genetic Creutzfeldt–Jakob disease (CJD) is associated with mutations in the
human PrP gene (PRNP) on chromosome 20p12-pter. Pathogenic mutations have been …

Creutzfeldt‐Jakob disease (CJD) is a human prion disease with different etiologies. To
determine the spectrum of tau pathologies in CJD, we assessed phospho‐Tau (pTau) …

The molecular and cellular mechanisms, which coordinate the critical stages of brain
development to reach a normal structural organization with appropriate networks, are …

Abstract Genetic Creutzfeldt-Jakob disease (gCJD) with E200K mutation is one of the
common subtypes of human genetic prion diseases worldwide. In this study, we …

The pathogenic aggregation of misfolded prion protein (PrP) in axons underlies prion
disease pathologies. The molecular mechanisms driving axonal misfolded PrP aggregate …

A novel point mutation resulting in a glutamate-to-glycine substitution in PRNP at codon 200,
E200G with codon 129 MV polymorphism (cis valine) and type 2 PrP Sc was identified in a …