Detection of cancer at an early stage when it is still localized improves patient response to
medical interventions for most cancer types. The success of screening tools such as cervical …

Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …

Nerves closely associate with blood vessels and help to pattern the vasculature during
development. Recent work suggests that newly formed nerve fibers may regulate the tumor …

During disease progression from primary towards metastatic prostate cancer (PCa), and in
particular bone metastases, the tumor microenvironment (TME) evolves in parallel with the …

The estrogenic properties of bisphenol A (BPA), a ubiquitous synthetic monomer that can
leach into the food and water supply, have prompted considerable research into exposure …

Lipids, either endogenously synthesized or exogenous, have been linked to human cancer.
Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate …

Prostate organogenesis is a complex process that is primarily mediated by the presence of
androgens and subsequent mesenchyme-epithelial interactions. The investigation of …

Combining immune checkpoint therapy (ICT) and targeted therapy holds great promises for
broad and long-lasting anti-cancer therapies. However, combining ICT with anti-PI3K …

Solid tumor growth and metastasis require the interaction of tumor cells with the surrounding
tissue, leading to a view of tumors as tissue-level phenomena rather than exclusively cell …

Most cancer patients do not die from the primary tumor but from its metastasis. Current in
vitro and in vivo cancer models are incapable of satisfactorily predicting the outcome of …